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Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase

Human NAD-dependent isocitrate dehydrogenase or HsIDH3 catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the TCA cycle. HsIDH3 exists and functions as a heterooctamer composed of the αβ and αγ heterodimers, and is regulated allosterically and/or competitively by numerous metabolite...

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Bibliographic Details
Published in:Cell Discov
Main Authors: Sun, Pengkai, Liu, Yan, Ma, Tengfei, Ding, Jianping
Format: Artigo
Language:Inglês
Published: Springer Singapore 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7752914/
https://ncbi.nlm.nih.gov/pubmed/33349631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-020-00220-7
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