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Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
Human NAD-dependent isocitrate dehydrogenase or HsIDH3 catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the TCA cycle. HsIDH3 exists and functions as a heterooctamer composed of the αβ and αγ heterodimers, and is regulated allosterically and/or competitively by numerous metabolite...
Guardat en:
| Publicat a: | Cell Discov |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer Singapore
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7752914/ https://ncbi.nlm.nih.gov/pubmed/33349631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-020-00220-7 |
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