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Molecular basis for the function of the αβ heterodimer of human NAD-dependent isocitrate dehydrogenase
Mammalian mitochondrial NAD-dependent isocitrate dehydrogenase (NAD-IDH) catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the tricarboxylic acid cycle. It exists as the α(2)βγ heterotetramer composed of the αβ and αγ heterodimers. Different from the αγ heterodimer that can be allo...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6827300/ https://ncbi.nlm.nih.gov/pubmed/31515270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010099 |
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