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Molecular basis for the function of the αβ heterodimer of human NAD-dependent isocitrate dehydrogenase

Mammalian mitochondrial NAD-dependent isocitrate dehydrogenase (NAD-IDH) catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the tricarboxylic acid cycle. It exists as the α(2)βγ heterotetramer composed of the αβ and αγ heterodimers. Different from the αγ heterodimer that can be allo...

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Vydáno v:J Biol Chem
Hlavní autoři: Sun, Pengkai, Ma, Tengfei, Zhang, Tianlong, Zhu, Hanwen, Zhang, Jianyang, Liu, Yabing, Ding, Jianping
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827300/
https://ncbi.nlm.nih.gov/pubmed/31515270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010099
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