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Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase
Human NAD-dependent isocitrate dehydrogenase catalyzes the decarboxylation of isocitrate (ICT) into α-ketoglutarate in the Krebs cycle. It exists as the α(2)βγ heterotetramer composed of the αβ and αγ heterodimers. Previously, we have demonstrated biochemically that the α(2)βγ heterotetramer and αγ...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5241874/ https://ncbi.nlm.nih.gov/pubmed/28098230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40921 |
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