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The β and γ subunits play distinct functional roles in the α(2)βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase

Human NAD-dependent isocitrate dehydrogenase existing as the α(2)βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. To explore the functional roles of the regulatory β and γ subunits, we sys...

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發表在:Sci Rep
Main Authors: Ma, Tengfei, Peng, Yingjie, Huang, Wei, Liu, Yabing, Ding, Jianping
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282582/
https://ncbi.nlm.nih.gov/pubmed/28139779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41882
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