Redox-resistant SERCA attenuates oxidant-stimulated mitochondrial calcium and apoptosis in cardiac myocytes and pressure overload-induced myocardial failure in mice

BACKGROUND. Sarco(endo)plasmic reticulum calcium ATPase (SERCA) is regulated by oxidative post-translational modifications at cysteine 674 (C674). Since sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in mediating mitochondrial dysfunction in response to reactive oxygen sp...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Goodman, Jena B., Qin, Fuzhong, Morgan, Robert J., Chambers, Jordan M., Croteau, Dominique, Siwik, Deborah A., Hobai, Ion, Panagia, Marcello, Luptak, Ivan, Bachschmid, Markus, Tong, XiaoYong, Pimentel, David R., Cohen, Richard A., Colucci, Wilson S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7752816/
https://ncbi.nlm.nih.gov/pubmed/33076678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.120.048183
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados