Redox-resistant SERCA attenuates oxidant-stimulated mitochondrial calcium and apoptosis in cardiac myocytes and pressure overload-induced myocardial failure in mice

BACKGROUND. Sarco(endo)plasmic reticulum calcium ATPase (SERCA) is regulated by oxidative post-translational modifications at cysteine 674 (C674). Since sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in mediating mitochondrial dysfunction in response to reactive oxygen sp...

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Published in:Circulation
Main Authors: Goodman, Jena B., Qin, Fuzhong, Morgan, Robert J., Chambers, Jordan M., Croteau, Dominique, Siwik, Deborah A., Hobai, Ion, Panagia, Marcello, Luptak, Ivan, Bachschmid, Markus, Tong, XiaoYong, Pimentel, David R., Cohen, Richard A., Colucci, Wilson S.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7752816/
https://ncbi.nlm.nih.gov/pubmed/33076678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.120.048183
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