Energetic Dysfunction Is Mediated by Mitochondrial Reactive Oxygen Species and Precedes Structural Remodeling in Metabolic Heart Disease

Aims: Metabolic syndrome is associated with metabolic heart disease (MHD) that is characterized by left ventricular (LV) hypertrophy, interstitial fibrosis, contractile dysfunction, and mitochondrial dysfunction. Overexpression of catalase in mitochondria (transgenic expression of catalase targeted...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Luptak, Ivan, Qin, Fuzhong, Sverdlov, Aaron L., Pimentel, David R., Panagia, Marcello, Croteau, Dominique, Siwik, Deborah A., Bachschmid, Markus M., He, Huamei, Balschi, James A., Colucci, Wilson S.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6648235/
https://ncbi.nlm.nih.gov/pubmed/31088291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2018.7707
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