Phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories revealed by AI-MiXeR

MOTIVATION: Determining the relative contributions of functional genetic categories is fundamental to understanding the genetic etiology of complex human traits and diseases. Here, we present Annotation Informed-MiXeR, a likelihood-based method for estimating the number of variants influencing a phe...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Bioinformatics
Hoofdauteurs: Shadrin, Alexey A, Frei, Oleksandr, Smeland, Olav B, Bettella, Francesco, O'Connell, Kevin S, Gani, Osman, Bahrami, Shahram, Uggen, Tea K E, Djurovic, Srdjan, Holland, Dominic, Andreassen, Ole A, Dale, Anders M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
Original Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750998/
https://ncbi.nlm.nih.gov/pubmed/32539089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa568
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items