Distinct patterns of genetic overlap among multimorbidities revealed with trivariate MiXeR

Abstract Background Multimorbidities are a global health challenge. Accumulating evidence indicates that overlapping genetic architectures underlie comorbid complex human traits and disorders. This can be quantified for a pair of phenotypes using various techniques. Still, the pattern of genetic ove...

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Hlavní autoři:	Alexey A. Shadrin, Guy Hindley, Espen Hagen, Nadine Parker, Markos Tesfaye, Piotr Jaholkowski, Zillur Rahman, Gleda Kutrolli, Vera Fominykh, Srdjan Djurovic, Olav B. Smeland, Kevin S. O’Connell, Dennis van der Meer, Oleksandr Frei, Ole A. Andreassen, Anders M. Dale
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-09-01
Edice:	Genome Medicine
Témata:	Multimorbidity Complex phenotypes The pattern of genetic overlap GWAS Trivariate MiXeR
On-line přístup:	https://doi.org/10.1186/s13073-025-01528-3
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