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HSATII RNA is induced via a noncanonical ATM-regulated DNA damage response pathway and promotes tumor cell proliferation and movement

Pericentromeric human satellite II (HSATII) repeats are normally silent but can be actively transcribed in tumor cells, where increased HSATII copy number is associated with a poor prognosis in colon cancer, and in human cytomegalovirus (HCMV)-infected fibroblasts, where the RNA facilitates viral re...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Nogalski, Maciej T., Shenk, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749351/
https://ncbi.nlm.nih.gov/pubmed/33257565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017734117
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