Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site

With a view to facilitating prediction of the exocyclic bond to the pyranoside ring in higher carbon sugars a model is advanced that relates the relative configuration of the three stereogenic centers comprised of the branchpoint and of the two flanking centers (C4–C5–C6 in aldoheptoses and higher,...

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Bibliographic Details
Published in:J Org Chem
Main Authors: Pirrone, Michael G., Gysin, Marina, Haldimann, Klara, Hobbie, Sven N., Vasella, Andrea, Crich, David
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749010/
https://ncbi.nlm.nih.gov/pubmed/32902280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.0c01836
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