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Synthesis of saccharocin from apramycin and evaluation of its ribosomal selectivity
We describe a straightforward synthesis of the apramycin biosynthetic precursor saccharocin from apramycin by regioselective partial azidation followed by stereoretentive oxidative deamination. Saccharocin was found to exhibit excellent selectivity for inhibition of the bacterial ribosome over the e...
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| Veröffentlicht in: | Medchemcomm |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Royal Society of Chemistry
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6482888/ https://ncbi.nlm.nih.gov/pubmed/31057735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00093c |
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