Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology

Mycolactone, a lipid-like toxin, is the major virulence factor of Mycobacterium ulcerans, the etiological agent of Buruli ulcer. Its involvement in lesion development has been widely described in early stages of the disease, through its cytotoxic and immunosuppressive activities, but less is known a...

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Udgivet i:PLoS Pathog
Main Authors: Foulon, M., Robbe-Saule, M., Manry, J., Esnault, L., Boucaud, Y., Alcaïs, A., Malloci, M., Fanton d’Andon, M., Beauvais, T., Labarriere, N., Jeannin, P., Abel, L., Saint-André, J. P., Croué, A., Delneste, Y., Boneca, I. G., Marsollier, L., Marion, E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7748131/
https://ncbi.nlm.nih.gov/pubmed/33338061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009107
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