Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology

Mycolactone, a lipid-like toxin, is the major virulence factor of Mycobacterium ulcerans, the etiological agent of Buruli ulcer. Its involvement in lesion development has been widely described in early stages of the disease, through its cytotoxic and immunosuppressive activities, but less is known a...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Foulon, M., Robbe-Saule, M., Manry, J., Esnault, L., Boucaud, Y., Alcaïs, A., Malloci, M., Fanton d’Andon, M., Beauvais, T., Labarriere, N., Jeannin, P., Abel, L., Saint-André, J. P., Croué, A., Delneste, Y., Boneca, I. G., Marsollier, L., Marion, E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7748131/
https://ncbi.nlm.nih.gov/pubmed/33338061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009107
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