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Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

[Image: see text] Antibodies are attractive as radioligands due to their outstanding specificity and high affinity, but their inability to cross the blood–brain barrier (BBB) limits their use for CNS targets. To enhance brain distribution, amyloid-β (Aβ) antibodies were fused to a transferrin recept...

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Vydáno v:ACS Chem Neurosci
Hlavní autoři: Syvänen, Stina, Fang, Xiaotian T, Faresjö, Rebecca, Rokka, Johanna, Lannfelt, Lars, Olberg, Dag E, Eriksson, Jonas, Sehlin, Dag
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2020
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7747219/
https://ncbi.nlm.nih.gov/pubmed/33236886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00652
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