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Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in the Pore of the α(2)β(3)γ(2) GABA(A) Receptor
Tetramethylenedisulfotetramine (TETS) is a so-called “caged” convulsant that is responsible for thousands of accidental and malicious poisonings. Similar to the widely used GABA receptor type A (GABA(A)) antagonist picrotoxinin, TETS has been proposed to bind to the noncompetitive antagonist (NCA) s...
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| Udgivet i: | Mol Pharmacol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Pharmacology and Experimental Therapeutics
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7746976/ https://ncbi.nlm.nih.gov/pubmed/33109687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.120.000090 |
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