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Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases
Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected. Among the mechanisms that have been suggested for this enigmatic phenomenon is dosage-sensitive compensation by paralogs of causal genes. Accord...
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| Vydáno v: | Comput Struct Biotechnol J |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Research Network of Computational and Structural Biotechnology
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7744645/ https://ncbi.nlm.nih.gov/pubmed/33363699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.10.030 |
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