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Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases

Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected. Among the mechanisms that have been suggested for this enigmatic phenomenon is dosage-sensitive compensation by paralogs of causal genes. Accord...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Jubran, Juman, Hekselman, Idan, Novack, Lena, Yeger-Lotem, Esti
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744645/
https://ncbi.nlm.nih.gov/pubmed/33363699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.10.030
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