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Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases
Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected. Among the mechanisms that have been suggested for this enigmatic phenomenon is dosage-sensitive compensation by paralogs of causal genes. Accord...
Gorde:
| Argitaratua izan da: | Comput Struct Biotechnol J |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Research Network of Computational and Structural Biotechnology
2020
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7744645/ https://ncbi.nlm.nih.gov/pubmed/33363699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.10.030 |
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