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Thioamide Substitution Selectively Modulates Proteolysis and Receptor Activity of Therapeutic Peptide Hormones
Peptide hormones are attractive as injectable therapeutics and imaging agents, but they often require extensive modification by mutagenesis and/or chemical synthesis to prevent rapid in vivo degradation. Alternatively, the single atom, O-to-S modification of peptide backbone thioamidation has the po...
Tallennettuna:
| Julkaisussa: | J Am Chem Soc |
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| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2017
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7744120/ https://ncbi.nlm.nih.gov/pubmed/29130686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08417 |
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