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Increasing the bioactive space of peptide macrocycles by thioamide substitution
We show that substituting a single atom, O to S (amide to thioamide), in a peptide bond results in global restriction of the conformational flexibility in peptide macrocycles with minimal perturbation of the parent conformation. The van der Waals interactions between the C[double bond, length as m-d...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5909342/ https://ncbi.nlm.nih.gov/pubmed/29732120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc04671e |
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