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Studies of Thioamide Effects on Serine Protease Activity Enable Two-Site Stabilization of Cancer Imaging Peptides

Thioamide substitutions in peptides can be used as fluorescence quenchers in protease sensors and as stabilizing modifications of hormone analogs. To guide these applications in the context of serine proteases, we here examine the cleavage of several model substrates, scanning a thioamide between th...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Barrett, Taylor M., Chen, Xing S., Liu, Chunxiao, Giannakoulias, Sam, Phan, Hoang Anh T., Wang, Jieliang, Keenan, E. Keith, Karpowicz, Richard J., Petersson, E. James
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7759718/
https://ncbi.nlm.nih.gov/pubmed/32141733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b01036
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