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An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility

Synaptic weight changes among postsynaptic densities within a single dendrite are regulated by the balance between localized protein degradation and synthesis. However, the molecular mechanism via these opposing regulatory processes is still elusive. Here, we showed that the molecular motor KIF17 wa...

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Publicat a:Sci Adv
Autors principals: Iwata, Suguru, Morikawa, Momo, Takei, Yosuke, Hirokawa, Nobutaka
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744090/
https://ncbi.nlm.nih.gov/pubmed/33328231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc8355
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