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An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility

Synaptic weight changes among postsynaptic densities within a single dendrite are regulated by the balance between localized protein degradation and synthesis. However, the molecular mechanism via these opposing regulatory processes is still elusive. Here, we showed that the molecular motor KIF17 wa...

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Bibliografische gegevens
Gepubliceerd in:Sci Adv
Hoofdauteurs: Iwata, Suguru, Morikawa, Momo, Takei, Yosuke, Hirokawa, Nobutaka
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Association for the Advancement of Science 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744090/
https://ncbi.nlm.nih.gov/pubmed/33328231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc8355
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