A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

Epitopes that are conserved among SARS-like coronaviruses are attractive targets for design of cross-reactive vaccines and therapeutics. CR3022 is a SARS-CoV neutralizing antibody to a highly conserved epitope on the receptor binding domain (RBD) on the spike protein that is able to cross-react with...

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Vydáno v:PLoS Pathog
Hlavní autoři: Wu, Nicholas C., Yuan, Meng, Bangaru, Sandhya, Huang, Deli, Zhu, Xueyong, Lee, Chang-Chun D., Turner, Hannah L., Peng, Linghang, Yang, Linlin, Burton, Dennis R., Nemazee, David, Ward, Andrew B., Wilson, Ian A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744049/
https://ncbi.nlm.nih.gov/pubmed/33275640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009089
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