Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

The protective efficacy of neutralizing antibodies (nAbs) elicited during natural infection with SARS-CoV-2 and by vaccination based on its spike protein has been compromised with emergence of the recent SARS-CoV-2 variants. Residues E484 and K417 in the receptor-binding site (RBS) are both mutated...

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Publicat a:bioRxiv
Autors principals: Yuan, Meng, Huang, Deli, Lee, Chang-Chun D., Wu, Nicholas C., Jackson, Abigail M., Zhu, Xueyong, Liu, Hejun, Peng, Linghang, van Gils, Marit J., Sanders, Rogier W., Burton, Dennis R., Reincke, S. Momsen, Prüss, Harald, Kreye, Jakob, Nemazee, David, Ward, Andrew B., Wilson, Ian A.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899451/
https://ncbi.nlm.nih.gov/pubmed/33619487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.02.16.430500
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