Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

The protective efficacy of neutralizing antibodies (nAbs) elicited during natural infection with SARS-CoV-2 and by vaccination based on its spike protein has been compromised with emergence of the recent SARS-CoV-2 variants. Residues E484 and K417 in the receptor-binding site (RBS) are both mutated...

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Published in:bioRxiv
Main Authors: Yuan, Meng, Huang, Deli, Lee, Chang-Chun D., Wu, Nicholas C., Jackson, Abigail M., Zhu, Xueyong, Liu, Hejun, Peng, Linghang, van Gils, Marit J., Sanders, Rogier W., Burton, Dennis R., Reincke, S. Momsen, Prüss, Harald, Kreye, Jakob, Nemazee, David, Ward, Andrew B., Wilson, Ian A.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899451/
https://ncbi.nlm.nih.gov/pubmed/33619487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.02.16.430500
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