Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial

INTRODUCTION: Allopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well‐established preclinical safety efficacy make it a viable candidate. METHODS: A randomized, doubl...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Alzheimers Dement (N Y)
Päätekijät: Hernandez, Gerson D., Solinsky, Christine M., Mack, Wendy J., Kono, Naoko, Rodgers, Kathleen E., Wu, Chun‐Yi, Mollo, Ana R., Lopez, Claudia M., Pawluczyk, Sonia, Bauer, Gerhard, Matthews, Dawn, Shi, Yonggang, Law, Meng, Rogawski, Michael A., Schneider, Lon S., Brinton, Roberta D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744018/
https://ncbi.nlm.nih.gov/pubmed/33344752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/trc2.12107
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