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Frontiers in therapeutic development of allopregnanolone for Alzheimer’s disease and other neurological disorders

Allopregnanolone (Allo), a neurosteroid, has emerged as a promising promoter of endogenous regeneration in brain. In a mouse model of Alzheimer’s disease, Allo induced neurogenesis, oligodendrogenesis, white matter generation and cholesterol homeostasis while simultaneously reducing β-amyloid and ne...

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Detalhes bibliográficos
Main Authors: Irwin, Ronald W., Solinsky, Christine M., Brinton, Roberta Diaz
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115668/
https://ncbi.nlm.nih.gov/pubmed/25126056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00203
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