Allopregnanolone Preclinical Acute Pharmacokinetic and Pharmacodynamic Studies to Predict Tolerability and Efficacy for Alzheimer’s Disease

To develop allopregnanolone as a therapeutic for Alzheimer’s disease, we investigated multiple formulations and routes of administration in translationally relevant animal models of both sexes. Subcutaneous, topical (transdermal and intranasal), intramuscular, and intravenous allopregnanolone were b...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Irwin, Ronald W., Solinsky, Christine M., Loya, Carlos M., Salituro, Francesco G., Rodgers, Kathleen E., Bauer, Gerhard, Rogawski, Michael A., Brinton, Roberta Diaz
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454520/
https://ncbi.nlm.nih.gov/pubmed/26039057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128313
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