Allopregnanolone Preclinical Acute Pharmacokinetic and Pharmacodynamic Studies to Predict Tolerability and Efficacy for Alzheimer’s Disease

To develop allopregnanolone as a therapeutic for Alzheimer’s disease, we investigated multiple formulations and routes of administration in translationally relevant animal models of both sexes. Subcutaneous, topical (transdermal and intranasal), intramuscular, and intravenous allopregnanolone were b...

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Publicat a:PLoS One
Autors principals: Irwin, Ronald W., Solinsky, Christine M., Loya, Carlos M., Salituro, Francesco G., Rodgers, Kathleen E., Bauer, Gerhard, Rogawski, Michael A., Brinton, Roberta Diaz
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454520/
https://ncbi.nlm.nih.gov/pubmed/26039057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128313
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