Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders

Allopregnanolone (Allo), a neurosteroid, has emerged as a promising promoter of endogenous regeneration in brain. In a mouse model of Alzheimer’s disease, Allo induced neurogenesis, oligodendrogenesis, white matter generation and cholesterol homeostasis while simultaneously reducing β-amyloid and ne...

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Detalhes bibliográficos
Main Authors: Ronald W. Irwin, Christine M. Solinsky, Roberta Diaz Brinton
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014-07-01
Colecção:Frontiers in Cellular Neuroscience
Assuntos:
Neurogenesis
Regeneration
Alzheimer's disease
β-Amyloid
myelin
Allopregnanolone
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00203/full
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