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NAD(+)/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro

Human mesenchymal stem cells (hMSCs) promote endogenous tissue regeneration and have become a promising candidate for cell therapy. However, in vitro culture expansion of hMSCs induces a rapid decline of stem cell properties through replicative senescence. Here, we characterize metabolic profiles of...

詳細記述

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書誌詳細
出版年:Commun Biol
主要な著者: Yuan, Xuegang, Liu, Yijun, Bijonowski, Brent M., Tsai, Ang-Chen, Fu, Qin, Logan, Timothy M., Ma, Teng, Li, Yan
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738682/
https://ncbi.nlm.nih.gov/pubmed/33319867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01514-y
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