NAD(+)/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro

Human mesenchymal stem cells (hMSCs) promote endogenous tissue regeneration and have become a promising candidate for cell therapy. However, in vitro culture expansion of hMSCs induces a rapid decline of stem cell properties through replicative senescence. Here, we characterize metabolic profiles of...

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Bibliografske podrobnosti
izdano v:Commun Biol
Main Authors: Yuan, Xuegang, Liu, Yijun, Bijonowski, Brent M., Tsai, Ang-Chen, Fu, Qin, Logan, Timothy M., Ma, Teng, Li, Yan
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738682/
https://ncbi.nlm.nih.gov/pubmed/33319867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01514-y
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