K(2P)2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury

No targeted therapies exist to counteract Hyperoxia (HO)-induced Acute Lung Injury (HALI). We previously found that HO downregulates alveolar K(2P)2.1 (TREK-1) K(+) channels, which results in worsening lung injury. This decrease in TREK-1 levels leaves a subset of channels amendable to pharmacologic...

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Publicado en:Sci Rep
Autores principales: Zyrianova, Tatiana, Lopez, Benjamin, Olcese, Riccardo, Belperio, John, Waters, Christopher M., Wong, Leanne, Nguyen, Victoria, Talapaneni, Sriharsha, Schwingshackl, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738539/
https://ncbi.nlm.nih.gov/pubmed/33319831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78886-y
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