Deficiency of the Two-Pore-Domain Potassium (K2P) Channel TREK-1 Promotes Hyperoxia-Induced Lung Injury

OBJECTIVE: We previously reported the expression of the 2-pore domain K(+) channel TREK-1 in lung epithelial cells and proposed a role for this channel in the regulation of alveolar epithelial cytokine secretion. In this study we focused on investigating the role of TREK-1 in vivo in the development...

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Hauptverfasser: Schwingshackl, Andreas, Teng, Bin, Makena, Patrudu, Ghosh, Manik, Sinclair, Scott E., Luellen, Charlean, Balasz, Louisa, Rovnaghi, Cynthia, Bryan, Robert M., Lloyd, Eric E., Fitzpatrick, Elizabeth, Saravia, Jordy S., Cormier, Stephania A., Waters, Christopher M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199872/
https://ncbi.nlm.nih.gov/pubmed/25126877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000000603
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