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Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes

Both high tidal volume mechanical ventilation (HV) and hyperoxia (HO) have been implicated in ventilator-induced lung injury. However, patients with acute lung injury are often exposed to HO before the application of mechanical ventilation. The potential priming of the lungs for subsequent injury by...

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Detalhes bibliográficos
Main Authors: Makena, Patrudu S., Luellen, Charlean L., Balazs, Louisa, Ghosh, Manik C., Parthasarathi, Kaushik, Waters, Christopher M., Sinclair, Scott E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980385/
https://ncbi.nlm.nih.gov/pubmed/20833778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00072.2010
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