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Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes

Both high tidal volume mechanical ventilation (HV) and hyperoxia (HO) have been implicated in ventilator-induced lung injury. However, patients with acute lung injury are often exposed to HO before the application of mechanical ventilation. The potential priming of the lungs for subsequent injury by...

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Главные авторы: Makena, Patrudu S., Luellen, Charlean L., Balazs, Louisa, Ghosh, Manik C., Parthasarathi, Kaushik, Waters, Christopher M., Sinclair, Scott E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980385/
https://ncbi.nlm.nih.gov/pubmed/20833778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00072.2010
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