The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells

Here, we screened steroid compounds to obtain a drug expected to block host inflammatory responses and Middle East respiratory syndrome coronavirus (MERS-CoV) replication. Ciclesonide, an inhaled corticosteroid, suppressed the replication of MERS-CoV and other coronaviruses, including severe acute r...

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Publicado en:J Virol
Autores principales: Matsuyama, Shutoku, Kawase, Miyuki, Nao, Naganori, Shirato, Kazuya, Ujike, Makoto, Kamitani, Wataru, Shimojima, Masayuki, Fukushi, Shuetsu
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737752/
https://ncbi.nlm.nih.gov/pubmed/33055254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01648-20
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