Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells

Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes host cellular proteases to enter cells. A previous report shows that furin, which is distributed mainly in the Golgi apparatus and cycled to the cell surface and endosomes, proteolytically activates the MERS-CoV spike (S) protein follo...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Matsuyama, Shutoku, Shirato, Kazuya, Kawase, Miyuki, Terada, Yutaka, Kawachi, Kengo, Fukushi, Shuetsu, Kamitani, Wataru
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146822/
https://ncbi.nlm.nih.gov/pubmed/30021905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00683-18
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