The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells

Here, we screened steroid compounds to obtain a drug expected to block host inflammatory responses and Middle East respiratory syndrome coronavirus (MERS-CoV) replication. Ciclesonide, an inhaled corticosteroid, suppressed the replication of MERS-CoV and other coronaviruses, including severe acute r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Matsuyama, Shutoku, Kawase, Miyuki, Nao, Naganori, Shirato, Kazuya, Ujike, Makoto, Kamitani, Wataru, Shimojima, Masayuki, Fukushi, Shuetsu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2020
Pynciau:
Vaccines and Antiviral Agents
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737752/
https://ncbi.nlm.nih.gov/pubmed/33055254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01648-20
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