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Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins

Amyloid proteins are involved in many neurodegenerative disorders such as Alzheimer’s disease [Tau, Amyloid β (Aβ)], Parkinson’s disease [alpha-synuclein (αSyn)], and amyotrophic lateral sclerosis (TDP-43). Driven by the early observation of the presence of ordered structure within amyloid fibrils a...

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Dades bibliogràfiques
Publicat a:Front Neurosci
Autors principals: Ulamec, Sabine M., Brockwell, David J., Radford, Sheena E.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736610/
https://ncbi.nlm.nih.gov/pubmed/33335475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.611285
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