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A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function
Aggregation of human α-synuclein (αSyn) is linked to Parkinson’s disease (PD) pathology. The central region of the αSyn sequence contains the non-amyloid β-component (NAC) crucial for aggregation. However, how NAC flanking regions modulate αSyn aggregation remains unclear. Using bioinformatics, muta...
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| 發表在: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7100612/ https://ncbi.nlm.nih.gov/pubmed/32157247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0384-x |
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