A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function

Aggregation of human α-synuclein (αSyn) is linked to Parkinson’s disease (PD) pathology. The central region of the αSyn sequence contains the non-amyloid β-component (NAC) crucial for aggregation. However, how NAC flanking regions modulate αSyn aggregation remains unclear. Using bioinformatics, muta...

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Publicado no:Nat Struct Mol Biol
Main Authors: Doherty, Ciaran P. A., Ulamec, Sabine M., Maya-Martinez, Roberto, Good, Sarah C., Makepeace, Jemma, Khan, G. Nasir, van Oosten-Hawle, Patricija, Radford, Sheena E., Brockwell, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7100612/
https://ncbi.nlm.nih.gov/pubmed/32157247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0384-x
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