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An Optimal “Click” Formulation Strategy for Antibody-Drug Conjugate Synthesis
As a versatile reaction for bioconjugation, Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC) has enormous potential in the synthesis of antibody-drug conjugates (ADCs). In order to optimize CuAAC-based ADC synthesis, we characterized kinetically different formulation processes by mimicking ADC syn...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7736079/ https://ncbi.nlm.nih.gov/pubmed/33071032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115808 |
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