Partitioning of cancer therapeutics in nuclear condensates

The nucleus contains diverse phase-separated condensates that compartmentalize and concentrate biomolecules with distinct physicochemical properties. Here we consider whether condensates concentrate small molecule cancer therapeutics such that their pharmacodynamic properties are altered. We found t...

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Foilsithe in:Science
Main Authors: Klein, Isaac A., Boija, Ann, Afeyan, Lena K., Hawken, Susana Wilson, Fan, Mengyang, Dall’Agnese, Alessandra, Oksuz, Ozgur, Henninger, Jonathan E., Shrinivas, Krishna, Sabari, Benjamin R., Sagi, Ido, Clark, Victoria E., Platt, Jesse M., Kar, Mrityunjoy, McCall, Patrick M., Zamudio, Alicia V., Manteiga, John C., Coffey, Eliot L., Li, Charles H., Hannett, Nancy M., Guo, Yang Eric, Decker, Tim-Michael, Lee, Tong Ihn, Zhang, Tinghu, Weng, Jing-Ke, Taatjes, Dylan J., Chakraborty, Arup, Sharp, Phillip A., Chang, Young Tae, Hyman, Anthony A., Gray, Nathanael S., Young, Richard A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735713/
https://ncbi.nlm.nih.gov/pubmed/32554597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz4427
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