Partitioning of cancer therapeutics in nuclear condensates

The nucleus contains diverse phase-separated condensates that compartmentalize and concentrate biomolecules with distinct physicochemical properties. Here we consider whether condensates concentrate small molecule cancer therapeutics such that their pharmacodynamic properties are altered. We found t...

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Publicado no:Science
Main Authors: Klein, Isaac A., Boija, Ann, Afeyan, Lena K., Hawken, Susana Wilson, Fan, Mengyang, Dall’Agnese, Alessandra, Oksuz, Ozgur, Henninger, Jonathan E., Shrinivas, Krishna, Sabari, Benjamin R., Sagi, Ido, Clark, Victoria E., Platt, Jesse M., Kar, Mrityunjoy, McCall, Patrick M., Zamudio, Alicia V., Manteiga, John C., Coffey, Eliot L., Li, Charles H., Hannett, Nancy M., Guo, Yang Eric, Decker, Tim-Michael, Lee, Tong Ihn, Zhang, Tinghu, Weng, Jing-Ke, Taatjes, Dylan J., Chakraborty, Arup, Sharp, Phillip A., Chang, Young Tae, Hyman, Anthony A., Gray, Nathanael S., Young, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735713/
https://ncbi.nlm.nih.gov/pubmed/32554597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz4427
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