HIV-1 VRC01 germline-targeting immunogens select distinct epitope-specific B cell receptors

Activating precursor B cell receptors of HIV-1 broadly neutralizing antibodies requires specifically-designed immunogens. Here, we compared the abilities of three such germline-targeting immunogens against the VRC01-class receptors to activate the targeted B cells in transgenic mice expressing the g...

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Veröffentlicht in:Immunity
Hauptverfasser: Lin, Yu-Ru, Rachael Parks, K., Weidle, Connor, Naidu, Anika S., Khechaduri, Arineh, Riker, Andrew O., Takushi, Brittany, Chun, Jung-Ho, Borst, Andrew J., Veesler, David, Stuart, Andrew, Agrawal, Parul, Gray, Matthew, Pancera, Marie, Huang, Po-Ssu, Stamatatos, Leonidas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735217/
https://ncbi.nlm.nih.gov/pubmed/33053332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.09.007
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