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Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core
VRC01 broadly neutralizing antibodies (bnAbs) target the CD4-binding site (CD4(BS)) of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein (Env). Unlike mature antibodies, corresponding VRC01 germline precursors poorly bind to Env. Immunogen design has mostly relied on glycan removal fr...
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| Publicat a: | eLife |
|---|---|
| Autors principals: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6237438/ https://ncbi.nlm.nih.gov/pubmed/30403372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37688 |
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