Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

VRC01 broadly neutralizing antibodies (bnAbs) target the CD4-binding site (CD4(BS)) of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein (Env). Unlike mature antibodies, corresponding VRC01 germline precursors poorly bind to Env. Immunogen design has mostly relied on glycan removal fr...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Borst, Andrew J, Weidle, Connor E, Gray, Matthew D, Frenz, Brandon, Snijder, Joost, Joyce, M Gordon, Georgiev, Ivelin S, Stewart-Jones, Guillaume BE, Kwong, Peter D, McGuire, Andrew T, DiMaio, Frank, Stamatatos, Leonidas, Pancera, Marie, Veesler, David
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237438/
https://ncbi.nlm.nih.gov/pubmed/30403372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37688
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