An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF‐induced necroptosis decisions

Balancing cell death is essential to maintain healthy tissue homeostasis and prevent disease. Tumor necrosis factor (TNF) not only activates nuclear factor κB (NFκB), which coordinates the cellular response to inflammation, but may also trigger necroptosis, a pro‐inflammatory form of cell death. Whe...

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Veröffentlicht in:Mol Syst Biol
Hauptverfasser: Oliver Metzig, Marie, Tang, Ying, Mitchell, Simon, Taylor, Brooks, Foreman, Robert, Wollman, Roy, Hoffmann, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734648/
https://ncbi.nlm.nih.gov/pubmed/33314666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20209677
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