Pan-Sigma Receptor Modulator RC-106 Induces Terminal Unfolded Protein Response In In Vitro Pancreatic Cancer Model

Pancreatic cancer (PC) remains one of the most lethal cancers worldwide. Sigma receptors (SRs) have been proposed as cancer therapeutic targets. Their main localization suggests they play a potential role in ER stress and in the triggering of the unfolded protein response (UPR). Here, we investigate...

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Udgivet i:Int J Mol Sci
Main Authors: Cortesi, Michela, Zamagni, Alice, Pignatta, Sara, Zanoni, Michele, Arienti, Chiara, Rossi, Daniela, Collina, Simona, Tesei, Anna
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734580/
https://ncbi.nlm.nih.gov/pubmed/33260926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239012
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