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Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

The past two decades have seen a shift from cytotoxic drugs to targeted therapy in medical oncology. Although targeted therapeutic agents have shown more impressive clinical efficacy and minimized adverse effects than traditional treatments, drug resistance has become the main limitation to their be...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Vis Exp
Hauptverfasser: Arienti, Chiara, Pignatta, Sara, Zanoni, Michele, Cortesi, Michela, Zamagni, Alice, Piccinini, Filippo, Tesei, Anna
Format: Artigo
Sprache:Inglês
Veröffentlicht: MyJove Corporation 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755558/
https://ncbi.nlm.nih.gov/pubmed/29286488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/56583
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